JP1302

CAT: 0804-HY-103213A-05Size: 100 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-103213A-05Size:100 mg

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Description

JP1302 is a potent, selective, high affinity antagonist of the α2C-adrenoceptor, with a Kb of 16 nM and a Ki of 28 nM for the human α2C-receptor. JP1302 shows antidepressant and antipsychotic-like effects. JP1302 can be used for neuropsychiatric disorders and renal dysfunction research[1][2][3].

CAS Number

80259-18-3

UNSPSC

12352005

Hazard Statement

H315, H319

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/jp1302.html

Purity

98.68

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

CN1CCN(C2=CC=C(NC3=C(C=CC=C4)C4=NC5=CC=CC=C53)C=C2)CC1

Molecular Formula

C24H24N4

Molecular Weight

368.47

Precautions

H315, H319

References & Citations

[1]Tricklebank MD, et al. JP-1302: a new tool to shed light on the roles of alpha2C-adrenoceptors in brain. Br J Pharmacol. 2007 Feb;150 (4) :381-2.|[2]Sallinen J, et al. Pharmacological characterization and CNS effects of a novel highly selective alpha2C-adrenoceptor antagonist JP-1302. Br J Pharmacol. 2007 Feb;150 (4) :391-402.|[3]Shimokawa T, et al. Post-treatment with JP-1302 protects against renal ischemia/reperfusion-induced acute kidney injury in rats. J Pharmacol Sci. 2019 Mar;139 (3) :137-142.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

α adrenergic receptor

Chemical Information

JP1302

alpha2C-adrenoceptor antagonist, may have therapeutic potential for treatment of neuropsychiatric disorders; structure in first source

CAS Number	80259-18-3
PubChem CID	540335
IUPAC Name	N-[4-(4-methylpiperazin-1-yl)phenyl]acridin-9-amine
Molecular Formula	C24H24N4
Molecular Weight	368.5
XLogP	5
Topological Polar Surface Area	31.4
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	3
Heavy Atom Count	28
Formal Charge	0
Complexity	473

SMILES

CN1CCN(CC1)C2=CC=C(C=C2)NC3=C4C=CC=CC4=NC5=CC=CC=C53

InChI

InChI=1S/C24H24N4/c1-27-14-16-28(17-15-27)19-12-10-18(11-13-19)25-24-20-6-2-4-8-22(20)26-23-9-5-3-7-21(23)24/h2-13H,14-17H2,1H3,(H,25,26)

InChIKey

QZKGUNQLVFEEBA-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 80259-18-3

CID: 540335

Formula: C24H24N4

MW: 368.5

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	368.5
XLogP3	5
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	3
Exact Mass	368.20009678
Monoisotopic Mass	368.20009678
Topological Polar Surface Area	31.4 Å²
Heavy Atom Count	28
Formal Charge	0
Complexity	473
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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JP1302

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