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HEMADO

CAT: 0804-HY-103187Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-103187Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HEMADO is a potent and selective adenosine A3 receptor agonist with a Ki of 1.1 nM at the human A3 subtype[1]. HEMADO is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
CAS Number
403842-38-6
UNSPSC
12352005
Hazard Statement
H302
Target
Adenosine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/hemado.html
Purity
99.0
Solubility
DMSO : 20 mg/mL (ultrasonic; warming)
Smiles
OC[C@@H]1[C@H]([C@H]([C@H](N2C=NC3=C2N=C(C#CCCCC)N=C3NC)O1)O)O
Molecular Formula
C17H23N5O4
Molecular Weight
361.40
Precautions
H302
References & Citations
[1]Klotz KN, et al. [3H]HEMADO— a novel tritiated agonist selective for the human adenosine A3 receptor. Eur J Pharmacol. 2007 Feb 5;556 (1-3) :14-8. Epub 2006 Oct 27.|[2]Volpini R, et al. N (6) -alkyl-2-alkynyl derivatives of adenosine as potent and selective agonists at the human adenosine A (3) receptor and a starting point for searching A (2B) ligands. J Med Chem. 2002 Jul 18;45 (15) :3271-9.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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