Br-PBTC

• Description :

  Br-PBTC is a potent, 2/4 subtype-selective positive allosteric modulator of nAChRs (nicotinic acetylcholine receptors) with α2β2, α2β4, α4β2, α4β4, (α4β2) 2α4 and (α4β2) 2β2 EC50 ranges from 0.1-0.6 μM. Br-PBTC acts from the c-tail of an α subunit[1].

• UNSPSC :

  12352005

• Target :

  NAChR

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/br-pbtc.html

• Purity :

  98.0

• Solubility :

  DMSO : 2 mg/mL (ultrasonic; warming)

• Smiles :

  O=C(C1=CC2=CC=CC(Br)=C2S1)N[C@H]3CNCCC3

• Molecular Formula :

  C14H15BrN2OS

• Molecular Weight :

  339.25

• References & Citations :

  [1]Wang J, et al. A Novel α2/α4 Subtype-selective Positive Allosteric Modulator of Nicotinic Acetylcholine Receptors Acting from the C-tail of an α Subunit. J Biol Chem. 2015;290 (48) :28834-28846.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1839519-57-1]