Products for Research Use Only
RegisterLogin

(R) -Afatinib

CAT: 0804-HY-10261ESize: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-10261ESize:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
(R) -Afatinib ((R) -BIBW 2992) is the Afatinib isomer. Afatinib is an orally active, potent and irreversible dual specificity inhibitor of?ErbB?family (EGFR?and?HER2), with?IC50?values of 0.5 nM, 0.4 nM, 10 nM and 14 nM for?EGFRwt, EGFRL858R, ?EGFRL858R/T790M?and HER2, respectively. Afatinib can be used for the research of esophageal squamous cell carcinoma (ESCC), non-small cell lung?cancer? (NSCLC) and gastric?cancer[1].
CAS Number
439081-17-1
Product Name Alternative
(R) -BIBW 2992
UNSPSC
12352005
Target
C-Met/HGFR; EGFR; p38 MAPK
Type
Reference compound
Related Pathways
JAK/STAT Signaling; MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/r-afatinib.html
Solubility
10 mM in DMSO
Smiles
CN(C)C/C=C/C(NC1=CC(C(NC2=CC(Cl)=C(C=C2)F)=NC=N3)=C3C=C1O[C@@H]4CCOC4)=O
Molecular Formula
C24H25ClFN5O3
Molecular Weight
485.94
References & Citations
[1]Li D, et al. BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models. Oncogene. 2008 Aug 7;27 (34) :4702-11.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-10261-01Afatinib
HY-10261DAfatinib (oxalate)
HY-10261S1-01Afatinib-d4
HY-10261A-01Afatinib (dimaleate)
HY-10261R-01Afatinib (Standard)
HY-10261S-01Afatinib-d6
HY-Z4740-01Afatinib impurity 90
HY-133780-01Afatinib impurity 11
HY-133110Afatinib N-Oxide
HY-Z3995-01Afatinib impurity 4

Alternative Products

CatalogName
A4746-25Afatinib

Popular Products