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Afatinib impurity 11

CAT: 0804-HY-133780-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-133780-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Afatinib impurity 11 is an impurity of Afatinib. Afatinib is an irreversible EGFR family inhibitor with IC50s of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively[1].
CAS Number
1402086-20-7
UNSPSC
12352005
Target
Autophagy; EGFR
Type
Reference compound
Related Pathways
Autophagy; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/afatinib-impurity-11.html
Purity
99.10
Solubility
DMSO : 20 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(NC1=C(C=C2C(C(NC3=CC(Cl)=C(C=C3)F)=NC=N2)=C1)O[C@H]4CCOC4)C=C
Molecular Formula
C21H18ClFN4O3
Molecular Weight
428.84
References & Citations
[1]Li D, et al. BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models. Oncogene. 2008 Aug 7;27 (34) :4702-11.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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Alternative Products

CatalogName
AR-A01479-01Afatinib Impurity A
AR-A01485-01Afatinib Impurity D (Z-Afatinib)
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AR-A01500-01Afatinib Impurity L (Afatinib N-Oxide)
RM-A062081-01Afatinib Impurity 81
RM-A062078-01Afatinib Impurity 78
RM-A062077-01Afatinib Impurity 77
RM-A062076-01Afatinib Impurity 76
RM-A062004-01Afatinib Impurity D
RM-A062009-01Afatinib Impurity I

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