Sorafenib-d4

CAT: 0804-HY-10201S1-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-10201S1-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Sorafenib-d4 (Bay 43-9006-d4) is the deuterium labeled Sorafenib. Sorafenib is a multikinase inhibitor IC50s of 6 nM, 20 nM, and 22 nM for Raf-1, B-Raf, and VEGFR-3, respectively.
CAS Number
[1207560-07-3]
Product Name Alternative
Bay 43-9006-d4
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Autophagy; Ferroptosis; FLT3; Raf; VEGFR
Type
Isotope-Labeled Compounds
Related Pathways
Apoptosis; Autophagy; MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Solubility
10 mM in DMSO
Smiles
O=C(C1=NC=CC(OC2=C([2H])C([2H])=C(NC(NC3=CC=C(Cl)C(C(F)(F)F)=C3)=O)C([2H])=C2[2H])=C1)NC
Molecular Formula
C21H12D4ClF3N4O3
Molecular Weight
468.85
Precautions
H302, H315, H319, H335
References & Citations
[1]Wilhelm SM, et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res. 2004 Oct 1;64 (19) :7099-109.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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