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Sorafenib-d3

CAT: 0804-HY-10201S-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-10201S-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Sorafenib-d3 (Donafenib), a deuterated compound of Sorafenib, is the first deuterium-generation tumor suppressor small molecule. Sorafenib is a multikinase inhibitor IC50s of 6 nM, 20 nM, and 22 nM for Raf-1, B-Raf, and VEGFR-3, respectively[1].
CAS Number
1130115-44-4
Product Name Alternative
Donafenib; Bay 43-9006-d3
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Autophagy; Ferroptosis; FLT3; Raf; VEGFR
Type
Isotope-Labeled Compounds
Related Pathways
Apoptosis; Autophagy; MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Purity
99.57
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=NC=CC(OC2=CC=C(NC(NC3=CC=C(Cl)C(C(F)(F)F)=C3)=O)C=C2)=C1)NC([2H])([2H])[2H]
Molecular Formula
C21H13D3ClF3N4O3
Molecular Weight
467.84
Precautions
H302, H315, H319, H335
References & Citations
[1]Wilhelm SM, et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res. 2004 Oct 1;64 (19) :7099-109.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
Launched

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