Uzansertib

CAT: 0804-HY-101870-02Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-101870-02Size:5 mg

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Description

Uzansertib (INCB053914) is an orally active, ATP-competitive pan-PIM kinase inhibitor with IC50s of 0.24 nM, 30 nM, 0.12 nM for PIM1, PIM2, PIM3, respectively. Uzansertib has broad anti-proliferative activity against a variety of hematologic tumor cell lines[1].

CAS Number

1620012-39-6

Product Name Alternative

INCB053914

UNSPSC

12352005

Target

Pim

Type

Reference compound

Related Pathways

JAK/STAT Signaling

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/uzansertib.html

Purity

99.45

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=NC(C2=C(F)C=CC=C2F)=C(F)C=C1)NC3=CN=C4C(CC[C@H]4O)=C3N5C[C@@H](N)[C@H](O)[C@@H](C)C5

Molecular Formula

C26H26F3N5O3

Molecular Weight

513.51

References & Citations

[1]Koblish H, et al. Preclinical characterization of INCB053914, a novel pan-PIM kinase inhibitor, alone and in combination with anticancer agents, in models of hematologic malignancies. PLoS One. 2018 Jun 21;13 (6) :e0199108.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 2

Isoform

PIM1; PIM2; PIM3

Chemical Information

Uzansertib

Uzansertib is under investigation in clinical trial NCT02587598 (Study of INCB053914 in Subjects With Advanced Malignancies).

CAS Number	1620012-39-6
PubChem CID	90279868
IUPAC Name	N-[(7R)-4-[(3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl]-7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl]-6-(2,6-difluorophenyl)-5-fluoropyridine-2-carboxamide
Molecular Formula	C26H26F3N5O3
Molecular Weight	513.5
XLogP	1.7
Topological Polar Surface Area	125
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	4
Heavy Atom Count	37
Formal Charge	0
Complexity	803

SMILES

C[C@H]1CN(C[C@H]([C@@H]1O)N)C2=C3CC[C@H](C3=NC=C2NC(=O)C4=NC(=C(C=C4)F)C5=C(C=CC=C5F)F)O

InChI

InChI=1S/C26H26F3N5O3/c1-12-10-34(11-17(30)25(12)36)24-13-5-8-20(35)22(13)31-9-19(24)33-26(37)18-7-6-16(29)23(32-18)21-14(27)3-2-4-15(21)28/h2-4,6-7,9,12,17,20,25,35-36H,5,8,10-11,30H2,1H3,(H,33,37)/t12-,17+,20+,25+/m0/s1

InChIKey

PTORCEYGCGXHDH-OVMXCRKPSA-N

Chemical Structure

2D Structure

CAS: 1620012-39-6

CID: 90279868

Formula: C26H26F3N5O3

MW: 513.5

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	513.5
XLogP3	1.7
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	4
Exact Mass	513.19877419
Monoisotopic Mass	513.19877419
Topological Polar Surface Area	125 Å²
Heavy Atom Count	37
Formal Charge	0
Complexity	803
Isotope Atom Count	0
Defined Atom Stereocenter Count	4
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
GTR19189554	Uzansertib
C13679-5mg	Uzansertib (INCB053914)
BUP09043-01	Uzansertib phosphate

Uzansertib

Chemical Information

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