ARQ 069

• Description :

  ARQ 069, an analog of ARQ 523, inhibits FGFR in an enantiospecific manner. ARQ 069 targets the unphosphorylated, inactive forms of FGFR1/FGFR2 kinases (IC50s of 0.84 μM and 1.23 μM, respectively) . ARQ 069 inhibits FGFR1/FGFR2 autophosphorylation (IC50s of 2.8 and 1.9 μM, respectively) through a mechanism in a non-ATP competitive dependent manner[1].

• CAS Number :

  [1314021-57-2]

• UNSPSC :

  12352005

• Target :

  FGFR

• Type :

  Reference compound

• Related Pathways :

  Protein Tyrosine Kinase/RTK

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/arq-069.html

• Solubility :

  10 mM in DMSO

• Smiles :

  NC1=NC=C2C[C@@H](C3=CC=CC=C3)C4=CC=CC=C4C2=N1

• Molecular Formula :

  C18H15N3

• Molecular Weight :

  273.33

• References & Citations :

  [1]Eathiraj S, et al. A novel mode of protein kinase inhibition exploiting hydrophobic motifs of autoinhibited kinases: discovery of ATP-independent inhibitors of fibroblast growth factor receptor. J Biol Chem. 2011 Jun 10;286 (23) :20677-87.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported