Harmane (Standard)

• Description :

  Harmane (Standard) is the analytical standard of Harmane. This product is intended for research and analytical applications. Harmane, a β-Carboline alkaloid (BCA), is a potent neurotoxin that causes severe action tremors and psychiatric manifestations. Harmane shows 1000-fold selectivity for I1-Imidazoline receptor (IC50=30 nM) over α2-adrenoceptor (IC50=18 μM) . Harmane is also a potent and selective inhibitor of monoamine oxidase (MAO) (IC50s=0.5 and 5 μM for human MAO A/B, respectively) . Harmane exhibits comutagenic effect[1][2][3][4].

• CAS Number :

  [486-84-0]

• UNSPSC :

  12352005

• Hazard Statement :

  H302-H315-H319-H335

• Target :

  Adrenergic Receptor; Imidazoline Receptor; Monoamine Oxidase; Reference Standards

• Type :

  Reference Standards

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling; Others

• Field of Research :

  Cancer; Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/harmane-standard.html

• Smiles :

  CC1=NC=CC2=C1NC3=C2C=CC=C3

• Molecular Formula :

  C12H10N2

• Molecular Weight :

  182.22

• Precautions :

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference Standards

• Clinical Information :

  No Development Reported

• Isoform :

  MAO-A; MAO-B; α adrenergic receptor