Harmine (Standard)

• Description:

  Harmine (Standard) is the analytical standard of Harmine. This product is intended for research and analytical applications. Harmine is a natural dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) inhibitor with anticancer and anti-inflammatory activities. Harmine has a high affinity of 5-HT2A serotonin receptor, with an Ki of 397 nM[1].

• Product Name Alternative:

  Telepathine (Standard)

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  5-HT Receptor; DYRK; Reference Standards

• Type:

  Reference Standards

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling; Others; Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/harmine-standard.html

• Purity:

  99.81

• Smiles:

  CC1=NC=CC2=C1NC3=C2C=CC(OC)=C3

• Molecular Formula:

  C13H12N2O

• Molecular Weight:

  212.25

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Glennon RA, et al. Binding of beta-carbolines and related agents at serotonin (5-HT (2) and 5-HT (1A) ), dopamine (D (2) ) and benzodiazepine receptors. Drug Alcohol Depend. 2000 Aug 1;60 (2) :121-32.|[2]Neumann F, et al. DYRK1A inhibition and cognitive rescue in a Down syndrome mouse model are induced by new fluoro-DANDY derivatives. Sci Rep. 2018 Feb 12;8 (1) :2859.|[3]Zhang L, et al. Harmine suppresses homologous recombination repair and inhibits proliferation of hepatoma cells. Cancer Biol Ther. 2015;16 (11) :1585-92.|[4]Zhong Z, et al. Treatment with harmine ameliorates functional impairment and neuronal death following traumatic brain injury. Mol Med Rep. 2015 Dec;12 (6) :7985-91.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C, sealed storage, away from light and moisture

• Scientific Category:

  Reference Standards

• Isoform:

  5-HT2 Receptor

• CAS Number:

  [442-51-3]