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DCG-IV

CAT: 0804-HY-101335Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-101335Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DCG-IV is a potent agonist of group II mGluRs with EC50s of 0.35 and 0.09 μM for mGlu2R and mGlu3R, reapectively. DCG-IV is also a competitive antagonist at group I (IC50: mGlu1R/5R=389/630 μM) and III receptors (IC50: mGlu4R/6R/7R/8R= 22.5/39.6/40.1/32 μM) . DCG-IV has anticonvulsive and neuroprotective effects[1][2].
CAS Number
[147782-19-2]
UNSPSC
12352211
Hazard Statement
H302, H319
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/dcg-iv.html
Purity
99.0
Solubility
H2O : ≥ 20 mg/mL
Smiles
O=C([C@H]1[C@H](C(O)=O)C1[C@H](N)C(O)=O)O
Molecular Formula
C7H9NO6
Molecular Weight
203.15
Precautions
H302, H319
References & Citations
[1]Brabet I, et al. Comparative effect of L-CCG-I, DCG-IV and gamma-carboxy-L-glutamate on all clonedmetabotropic glutamate receptor subtypes. Neuropharmacology. 1998 Aug;37 (8) :1043-51.|[2]Bertrand HO, et al. Common and selective molecular determinants involved in metabotopic glutamate receptoragonist activity. J Med Chem. 2002 Jul 18;45 (15) :3171-83.|[3]Uyama Y, et al. DCG-IV, a potent metabotropic glutamate receptor agonist, as an NMDA receptor agonist in the rat cortical slice. Brain Res. 1997 Mar 28;752 (1-2) :327-30.|[4]Tomita N, et al. The effects of DCG-IV and L-CCG-1 upon phencyclidine (PCP) -induced locomotion and behavioral changes in mice. Ann N Y Acad Sci. 2000 Sep;914:284-91.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MGluR1; mGluR2; mGluR3; mGluR4; mGluR5; mGluR6; mGluR7; mGluR8

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