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TRIM

CAT: 0804-HY-101316Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-101316Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TRIM is a potent nitric oxide synthase inhibitor. TRIM inhibits mouse cerebellar nNOS and rat lung iNOS in vitro with IC50 values of 28.2 and 27.0 μM, respectively. Antidepressant- and anxiolytic-like effects[1][2].
CAS Number
25371-96-4
UNSPSC
12352005
Hazard Statement
H315-H319-H335
Target
NO Synthase
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/trim.html
Purity
99.90
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
FC(C1=CC=CC=C1N2C=CN=C2)(F)F
Molecular Formula
C10H7F3N2
Molecular Weight
212.17
Precautions
P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501
References & Citations
[1]Handy RL, et al. The antinociceptive effect of 1- (2-trifluoromethylphenyl) imidazole (TRIM), a potent inhibitor of neuronal nitric oxide synthase in vitro, in the mouse. Br J Pharmacol. 1995;116 (5) :2349-2350. |[2]Volke V, et al. Antidepressant- and anxiolytic-like effects of selective neuronal NOS inhibitor 1- (2-trifluoromethylphenyl) -imidazole in mice. Behav Brain Res. 2003;140 (1-2) :141-147.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
INOS; nNOS

Chemical Information

Trim

1-[2-(trifluoromethyl)phenyl]imidazole is a member of imidazoles.

CAS Number25371-96-4
PubChem CID1359
IUPAC Name1-[2-(trifluoromethyl)phenyl]imidazole
Molecular FormulaC10H7F3N2
Molecular Weight212.17
XLogP2.6
Topological Polar Surface Area17.8
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count1
Heavy Atom Count15
Formal Charge0
Complexity217
SMILES
C1=CC=C(C(=C1)C(F)(F)F)N2C=CN=C2
InChI
InChI=1S/C10H7F3N2/c11-10(12,13)8-3-1-2-4-9(8)15-6-5-14-7-15/h1-7H
InChIKey
WZBWBNCQUTXYEL-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Trim
CAS: 25371-96-4
CID: 1359
Formula: C10H7F3N2
MW: 212.17
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight212.17
XLogP32.6
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count1
Exact Mass212.05613272
Monoisotopic Mass212.05613272
Topological Polar Surface Area17.8 Ų
Heavy Atom Count15
Formal Charge0
Complexity217
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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