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TRIM

CAT: 0804-HY-101316Size: 50 mgDry Ice: NoHazardous: No
CAT#:0804-HY-101316Size:50 mg
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Description
TRIM is a potent nitric oxide synthase inhibitor. TRIM inhibits mouse cerebellar nNOS and rat lung iNOS in vitro with IC50 values of 28.2 and 27.0 μM, respectively. Antidepressant- and anxiolytic-like effects[1][2].
CAS Number
[25371-96-4]
UNSPSC
12352005
Hazard Statement
H315-H319-H335
Target
NO Synthase
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/trim.html
Purity
99.90
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
FC(C1=CC=CC=C1N2C=CN=C2)(F)F
Molecular Formula
C10H7F3N2
Molecular Weight
212.17
Precautions
P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501
References & Citations
[1]Handy RL, et al. The antinociceptive effect of 1- (2-trifluoromethylphenyl) imidazole (TRIM), a potent inhibitor of neuronal nitric oxide synthase in vitro, in the mouse. Br J Pharmacol. 1995;116 (5) :2349-2350. |[2]Volke V, et al. Antidepressant- and anxiolytic-like effects of selective neuronal NOS inhibitor 1- (2-trifluoromethylphenyl) -imidazole in mice. Behav Brain Res. 2003;140 (1-2) :141-147.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
INOS; nNOS

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