Products for Research Use Only
RegisterLogin

Masitinib (mesylate)

CAT: 0804-HY-10209A-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-10209A-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Masitinib mesylate (AB-1010 mesylate) is a potent, orally bioavailable, and selective inhibitor of c-Kit (IC50=200 nM for human recombinant c-Kit) . It also inhibits PDGFRα/β (IC50s=540/800 nM), Lyn (IC50= 510 nM for LynB), Lck, and, to a lesser extent, FGFR3 and FAK. Masitinib mesylate (AB-1010 mesylate) has anti-proliferative, pro-apoptotic activity and low toxicity[1][2][4].
CAS Number
1048007-93-7
Product Name Alternative
AB-1010 mesylate
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; c-Kit; FGFR; PDGFR; Src
Type
Reference compound
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/masitinib-mesylate.html
Purity
99.98
Solubility
1M HCl : 100 mg/mL (ultrasonic; adjust pH to 1 with HCl) |DMSO : ≥ 30 mg/mL
Smiles
O=C(NC1=CC=C(C(NC2=NC(C3=CC=CN=C3)=CS2)=C1)C)C4=CC=C(CN5CCN(CC5)C)C=C4.CS(=O)(O)=O
Molecular Formula
C29H34N6O4S2
Molecular Weight
594.75
Precautions
H302, H315, H319, H335
References & Citations
[1]Dubreuil P, et al. Masitinib (AB1010), a Potent and Selective Tyrosine Kinase Inhibitor Targeting KIT. PLoS One, 2009, 4 (9), e7258.|[2]Lawrence J, et al. Masitinib demonstrates anti-proliferative and pro-apoptotic activity in primary and metastatic feline injection-site sarcoma cells. Vet Comp Oncol, 2011, doi: 10.1111/j.1476-5829.2011.00291.x.|[3]Hahn KA, et al. Masitinib is safe and effective for the treatment of canine mast cell tumors. J Vet Intern Med, 2008, 22 (6), 1301-1309.|[4]Marech I, et al. Masitinib (AB1010), from canine tumor model to human clinical development: where we are? Crit Rev Oncol Hematol. 2014 Jul;91 (1) :98-111.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Citation 01
University of Heidelberg. 2025.|BMC Vet Res. 2020 Feb 19;16 (1) :64.|Ecotoxicol Environ Saf. 2025 Jun 4:300:118460.|Eur J Pharmacol. 2021 Nov 15:911:174549.|Harvard Medical School LINCS LIBRARY|Sci Transl Med. 2018 Jul 18;10 (450) :eaaq1093.|Science. 2021 Nov 26;374 (6571) :1099-1106.

Related Products

CatalogName
HY-10209-01Masitinib
HY-10209R-01Masitinib (Standard)
HY-101169Tetrindole (mesylate)
HY-B0501-01Danofloxacin (mesylate)
HY-14560C-01Reboxetine (mesylate)
HY-B0794B-01AZ7550 Mesylate
HY-B0520A-01Benztropine (mesylate)
HY-B0098A-01Doxazosin (mesylate)
HY-101560ALinrodostat (mesylate)
HY-100412ALinaprazan (mesylate)

Alternative Products

CatalogName
TRC-M104800-25MGMasitinib Mesylate
A15152-10Masitinib mesylate 10mg
A15152-5Masitinib mesylate 5mg
A15152-200Masitinib mesylate 200mg
A15152-100Masitinib mesylate 100mg
A15152-50Masitinib mesylate 50mg
A15152-25Masitinib mesylate 25mg
A15152-500Masitinib mesylate 500mg
A15152-10mM-DMasitinib mesylate 10mM * 1mL in DMSO
7705/50Masitinib

Popular Products