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(S) -Monastrol

CAT: 0804-HY-101071Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-101071Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(S) -Monastrol ((+) -Monastrol) is an allosteric inhibitor of the mitotic kinesin Eg5 that exhibits an antiproliferative effect against several cancer cell lines. (S) -Monastrol arrests mammalian cells in mitosis with monopolar spindles[1][2].
CAS Number
254753-54-3
Product Name Alternative
(+) -Monastrol
UNSPSC
12352005
Hazard Statement
H302-H312-H332
Target
Kinesin; Mitosis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/s-monastrol.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=C(C)NC(N[C@H]1C2=CC=CC(O)=C2)=S)OCC
Molecular Formula
C14H16N2O3S
Molecular Weight
292.35
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501
References & Citations
[1]Marques LA, et al. Antiproliferative activity of monastrol in human adenocarcinoma (MCF-7) and non-tumor (HB4a) breast cells. Naunyn Schmiedebergs Arch Pharmacol. 2016 Dec;389 (12) :1279-1288.|[2]Mayer TU, et al. Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen. Science. 1999 Oct 29;286 (5441) :971-4.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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