(2E) -OBAA

• Description:

  (2E) -OBAA is a potent phospholipase A2 (PLA2) inhibitor, with an IC50 of 70 nM. (2E) -OBAA induces apoptosis of HUVEC cells. (2E) -OBAA blocks Melittin-induced Ca2+ influx in Trypanosoma brucei, with an IC50 of 0.4 μM[1][2][3][4].

• UNSPSC:

  12352005

• Target:

  Apoptosis; Phospholipase

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Metabolic Enzyme/Protease

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/2e-obaa.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C (O) /C=C/C (C1=CC=C (CCCCCCCCCCCCCCCCCC) C=C1) =O

• Molecular Formula:

  C28H44O3

• Molecular Weight:

  428.66

• References & Citations:

  [1]J Y Miao, et al. Inhibitors of phospholipase promote apoptosis of human endothelial cells. J Biochem. 1997 Mar;121 (3) :612-8.|[2]J Eintracht, et al. Calcium entry in Trypanosoma brucei is regulated by phospholipase A2 and arachidonic acid. Biochem J. 1998 Dec 15;336 (Pt 3) (Pt 3) :659-66.|[3]T Köhler, et al. Phospholipase A2 inhibition by alkylbenzoylacrylic acids. Biochem Pharmacol. 1992 Aug 18;44 (4) :805-13.|[4]Kethineedi VR, et al. Quantum dot-NBD-liposome luminescent probes for monitoring phospholipase A2 activity. Anal Bioanal Chem. 2013 Dec;405 (30) :9729-37.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Phospholipase A

• CAS Number:

  221632-26-4