(2E) -OBAA

• Description :

  (2E) -OBAA is a potent phospholipase A2 (PLA2) inhibitor, with an IC50 of 70 nM. (2E) -OBAA induces apoptosis of HUVEC cells. (2E) -OBAA blocks Melittin-induced Ca2+ influx in Trypanosoma brucei, with an IC50 of 0.4 μM[1][2][3][4].

• UNSPSC :

  12352005

• Target :

  Apoptosis; Phospholipase

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Metabolic Enzyme/Protease

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/2e-obaa.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(O)/C=C/C(C1=CC=C(CCCCCCCCCCCCCCCCCC)C=C1)=O

• Molecular Formula :

  C28H44O3

• Molecular Weight :

  428.66

• References & Citations :

  [1]J Y Miao, et al. Inhibitors of phospholipase promote apoptosis of human endothelial cells. J Biochem. 1997 Mar;121 (3) :612-8.|[2]J Eintracht, et al. Calcium entry in Trypanosoma brucei is regulated by phospholipase A2 and arachidonic acid. Biochem J. 1998 Dec 15;336 (Pt 3) (Pt 3) :659-66.|[3]T Köhler, et al. Phospholipase A2 inhibition by alkylbenzoylacrylic acids. Biochem Pharmacol. 1992 Aug 18;44 (4) :805-13.|[4]Kethineedi VR, et al. Quantum dot-NBD-liposome luminescent probes for monitoring phospholipase A2 activity. Anal Bioanal Chem. 2013 Dec;405 (30) :9729-37.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Phospholipase A

• CAS Number :

  [221632-26-4]