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EPI-589

CAT: 0804-HY-125999-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-125999-01Size:5 mg
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Description
EPI-589, a quinone derivative, is a safe and well tolerated oxidoreductase enzyme inhibitor and a free radical scavenger, with blood-brain barrier permeable and orally available. EPI-589 is a redox-active neuroprotectant that effectively delays the symptoms of motor neuron disease in wobbler mice. EPI-589 can be used in amyotrophic lateral sclerosis (ALS) research[1][2][3][4].
CAS Number
[1147883-03-1]
UNSPSC
12352211
Target
Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/epi-589.html
Purity
99.34
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC1=C(C(C(CC[C@@](O)(C(N)=O)C)=C(C1=O)C)=O)C
Molecular Formula
C14H19NO4
Molecular Weight
265.30
References & Citations
[1]BioElectron’s EPI-589 Shows Positive Results in ALS Patients in Phase 2a Trial|[2]Phase IIa trial of EPI-589 in ALS shows improvement in CSF|[3]Ng N, et al. Mitochondrial therapeutics and mitochondrial transfer for neurodegenerative diseases and aging. Neural Regen Res. 2025 Mar 1;20 (3) :794-796.|[4]Matsumoto Y, et al. EPI-589, a redox-active neuroprotectant, potently protects cultured cells from oxidative stress and alleviates symptomatic and pathological progression of motor neuron disease in the wobbler mouse[J]. bioRxiv, 2022: 2022.03. 13.484182.|[5]Martinez A, et al. Drugs in clinical development for the treatment of amyotrophic lateral sclerosis[J]. Expert opinion on investigational drugs, 2017, 26 (4) : 403-414.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2

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