EPI-589

• Description :

  EPI-589, a quinone derivative, is a safe and well tolerated oxidoreductase enzyme inhibitor and a free radical scavenger, with blood-brain barrier permeable and orally available. EPI-589 is a redox-active neuroprotectant that effectively delays the symptoms of motor neuron disease in wobbler mice. EPI-589 can be used in amyotrophic lateral sclerosis (ALS) research[1][2][3][4].

• UNSPSC :

  12352211

• Target :

  Reactive Oxygen Species (ROS)

• Type :

  Reference compound

• Related Pathways :

  Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Applications :

  Neuroscience-Neurodegeneration

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/epi-589.html

• Purity :

  99.34

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  CC1=C(C(C(CC[C@@](O)(C(N)=O)C)=C(C1=O)C)=O)C

• Molecular Formula :

  C14H19NO4

• Molecular Weight :

  265.30

• References & Citations :

  [1]BioElectron’s EPI-589 Shows Positive Results in ALS Patients in Phase 2a Trial|[2]Phase IIa trial of EPI-589 in ALS shows improvement in CSF|[3]Ng N, et al. Mitochondrial therapeutics and mitochondrial transfer for neurodegenerative diseases and aging. Neural Regen Res. 2025 Mar 1;20 (3) :794-796.|[4]Matsumoto Y, et al. EPI-589, a redox-active neuroprotectant, potently protects cultured cells from oxidative stress and alleviates symptomatic and pathological progression of motor neuron disease in the wobbler mouse[J]. bioRxiv, 2022: 2022.03. 13.484182.|[5]Martinez A, et al. Drugs in clinical development for the treatment of amyotrophic lateral sclerosis[J]. Expert opinion on investigational drugs, 2017, 26 (4) : 403-414.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2

• CAS Number :

  [1147883-03-1]