D-Serine-d3

CAT: 0804-HY-100808SSize: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-100808SSize:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
D-Serine-d3 ((R) -Serine-d3) is a deuterium labeled D-Serine (HY-100808) . D-Serine ((R) -Serine), an endogenous amino acid involved in glia-synapse interactions that has unique neurotransmitter characteristics, is a potent co-agonist at the NMDA glutamate receptor. D-Serinee has a cardinal modulatory role in major NMDAR-dependent processes including NMDAR-mediated neurotransmission, neurotoxicity, synaptic plasticity, and cell migration[1][2][3].
CAS Number
[1414348-52-9]
Product Name Alternative
(R) -Serine-d3
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Endogenous Metabolite; iGluR; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; Others
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Purity
96.36
Solubility
H2O : 50 mg/mL (ultrasonic; warming)
Smiles
OC([C@@](N)([2H])C([2H])([2H])O)=O
Molecular Formula
C3H4D3NO3
Molecular Weight
108.11
Precautions
H302, H315, H319, H335
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-246.|[2]Andrea R. Durrant, et al. D-Serine in Neuropsychiatric Disorders: New Advances.|[3]MacKay MB, et al. D-Serine: Potential Therapeutic Agent and/or Biomarker in Schizophrenia and Depression Front Psychiatry. 2019 Feb 6;10:25.|[4]Dai X, et al. D-Serine made by serine racemase in Drosophila intestine plays a physiological role in sleep. Nat Commun. 2019 May 7;10 (1) :1986.|[5]Suwandhi L, et al. Chronic d-serine supplementation impairs insulin secretion. Mol Metab. 2018 Oct;16:191-202.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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