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D-Serine

CAT: 0804-HY-100808-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-100808-01Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
D-Serine ((R) -Serine), an endogenous amino acid involved in glia-synapse interactions that has unique neurotransmitter characteristics, is a potent co-agonist at the NMDA glutamate receptor. D-Serinee has a cardinal modulatory role in major NMDAR-dependent processes including NMDAR-mediated neurotransmission, neurotoxicity, synaptic plasticity, and cell migration[1][2].
CAS Number
312-84-5
Product Name Alternative
(R) -Serine
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Endogenous Metabolite; iGluR
Type
Natural Products
Related Pathways
Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/_R_-Serine.html
Purity
98.0
Solubility
H2O : ≥ 50 mg/mL|Methanol : < 1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
N[C@H](CO)C(O)=O
Molecular Formula
C3H7NO3
Molecular Weight
105.09
Precautions
H302, H315, H319, H335
References & Citations
[1]Andrea R. Durrant, et al. D-Serine in Neuropsychiatric Disorders: New Advances.|[2]MacKay MB, et al. D-Serine: Potential Therapeutic Agent and/or Biomarker in Schizophrenia and Depression? Front Psychiatry. 2019 Feb 6;10:25.|[3]Dai X, et al. D-Serine made by serine racemase in Drosophila intestine plays a physiological role in sleep. Nat Commun. 2019 May 7;10 (1) :1986.|[4]Suwandhi L, et al. Chronic d-serine supplementation impairs insulin secretion. Mol Metab. 2018 Oct;16:191-202.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
Launched
Isoform
Human Endogenous Metabolite; NMDA Receptor

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