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Cetirizine Impurity D

CAT: 0804-HY-100661Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-100661Size:1 Each
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Description
Cetirizine Impurity D is an impurity of Cetirizine. Cetirizine, a second-generation antihistamine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response[1][2][3].
CAS Number
346451-15-8
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Histamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/cetirizine-impurity-d.html
Solubility
10 mM in DMSO
Smiles
ClC1=CC=C(C(N2CCN(C(C3=CC=C(Cl)C=C3)C4=CC=CC=C4)CC2)C5=CC=CC=C5)C=C1
Molecular Formula
C30H28Cl2N2
Molecular Weight
487.46
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
References & Citations
[1]Caroline M. Spencer, et al. Cetirizine. Drugs 46 (6) : 1055-1080, 1993.|[2]Shih MY, et al. Influence of cetirizine and levocetirizine on two cytokines secretion in human airway epithelial cells. Allergy Asthma Proc. 2008 Sep-Oct;29 (5) :480-5.|[3]Shimizu T, et al. Cetirizine, an H1-receptor antagonist, suppresses the expression of macrophage migration inhibitory factor: its potential anti-inflammatory action. Clin Exp Allergy. 2004 Jan;34 (1) :103-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
H1 Receptor

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