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Lesogaberan

CAT: 0804-HY-10061Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-10061Size:1 Each
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Description
Lesogaberan (AZD-3355) is a potent and selective GABAB receptor agonist with an EC50 of 8.6 nM for human recombinant GABAB receptors. The affinity (Kis) of Lesogaberan for rat GABAB and GABAA receptors, as measured by displacement of [3H]GABA binding in brain membranes: 5.1 nM and 1.4 μM, respectively. Lesogaberan inhibits transient lower esophageal sphincter relaxation through a peripheral mode of action[1].
CAS Number
344413-67-8
Product Name Alternative
AZD-3355
UNSPSC
12352211
Hazard Statement
H302-H412
Target
GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/lesogaberan.html
Solubility
10 mM in DMSO
Smiles
O=P(O)C[C@H](F)CN
Molecular Formula
C3H9FNO2P
Molecular Weight
141.08
Precautions
P264-P270-P273-P330-P501
References & Citations
[1]Lehmann A, et al. (R) - (3-amino-2-fluoropropyl) phosphinic acid (AZD3355), a novel GABAB receptor agonist, inhibits transient lower esophageal sphincter relaxation through a peripheral mode of action. J Pharmacol Exp Ther. 2009 Nov;331 (2) :504-12.|[2]Tian J, et al. Repurposing Lesogaberan to Promote Human Islet Cell Survival and β-Cell Replication. J Diabetes Res. 2017;2017:6403539.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2

Alternative Products

CatalogName
TRC-L349570-50MGLesogaberan
MBS5800793Lesogaberan napadisylate
MBS5814673Lesogaberan hydrochloride

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