Sp-cAMPS

CAT: 0804-HY-100530BSize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-100530BSize:1 Each
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Description
Sp-cAMPS, a cAMP analog, is potent activator of cAMP-dependent PKA I and PKA II. Sp-cAMPS is also a potent, competitive phosphodiesterase (PDE3A) inhibitor with a Ki of 47.6 µM. Sp-cAMPS binds the PDE10 GAF domain with an EC50 of 40 μM[1][2][3].
CAS Number
[71774-13-5]
UNSPSC
12352005
Target
Phosphodiesterase (PDE) ; PKA
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Stem Cell/Wnt; TGF-beta/Smad
Applications
Neuroscience-Neuromodulation
Field of Research
Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/sp-camps.html
Solubility
10 mM in DMSO
Smiles
O[C@H]1[C@@H](O[C@@]2([H])[C@@]1([H])O[P@](OC2)(S)=O)N3C4=C(C(N)=NC=N4)N=C3
Molecular Formula
C10H12N5O5PS
Molecular Weight
345.27
References & Citations
[1]Su H Hung, et al. A new nonhydrolyzable reactive cAMP analog, (Sp) -adenosine-3',5'-cyclic-S- (4-bromo-2,3-dioxobutyl) monophosphorothioate irreversibly inactivates human platelet cGMP-inhibited cAMP phosphodiesterase. Bioorg Chem. 2002 Feb;30 (1) :16-31.|[2]L Y Wang, et al. Regulation of kainate receptors by cAMP-dependent protein kinase and phosphatases. Science. 1991 Sep 6;253 (5024) :1132-5.|[3]Ronald Jäger, et al. Activation of PDE10 and PDE11 phosphodiesterases. J Biol Chem. 2012 Jan 6;287 (2) :1210-9.|[4]P A Connelly, et al. A study of the mechanism of glucagon-induced protein phosphorylation in isolated rat hepatocytes using (Sp) -cAMPS and (Rp) -cAMPS, the stimulatory and inhibitory diastereomers of adenosine cyclic 3',5'-phosphorothioate. J Biol Chem. 1987 Mar 25;262 (9) :4324-32.|[5]G Dominguez, et al. Rescuing prefrontal cAMP-CREB pathway reverses working memory deficits during withdrawal from prolonged alcohol exposure. Brain Struct Funct. 2016 Mar;221 (2) :865-77.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDE10; PDE3; PKA

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