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Dehydroaltenusin

CAT: 0804-HY-100513ASize: InquireDry Ice: NoHazardous: No
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CAT#:0804-HY-100513ASize:Inquire
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
31186-13-7
UNSPSC Description
Dehydroaltenusin is a small molecule selective inhibitor of eukaryotic DNA polymerase α, a type of antibiotic produced by a fungus with an IC50 value of 0.68 μM. The inhibitory mode of action of dehydroaltenusin against mammalian pol α activity is competitive with respect to the DNA template primer (Ki=0.23 μM) and non-competitive with respect to the 2'-deoxyribonucleoside 5'-triphosphate substrate (Ki=0.18 μM)[1]. Dehydroaltenusin arrests the cancer cell cycle at the S-phase and triggers apoptosis[1]. Dehydroaltenusin possesses anti-tumor activity against human adenocarcinoma tumor in vivo[1].
Target Antigen
Antibiotic; Apoptosis; DNA/RNA Synthesis
Type
Natural Products
Related Pathways
Anti-infection;Apoptosis;Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dehydroaltenusin.html
Solubility
10 mM in DMSO
Smiles
O=C(C(O)=C1)C=C(C2=CC(OC)=CC(O)=C23)[C@@]1(C)OC3=O
Molecular Weight
288.25
References & Citations
[1]Mizushina Y, et al. Dehydroaltenusin is a specific inhibitor of mammalian DNA polymerase α. Expert Opin Investig Drugs. 2011 Nov;20(11):1523-34.
Shipping Conditions
Room temperature
Clinical Information
No Development Reported

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