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(±) -Dehydroaltenusin

CAT: 0931-TN11560-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-TN11560-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
34279-44-2
Target
Apoptosis, DNA/RNA Synthesis, Antibiotic
Related Pathways
Cell Cycle/Checkpoint, Microbiology/Virology, Apoptosis, DNA Damage/DNA Repair
Bioactivity
(±) -Dehydroaltenusin is an antibiotic that serves as a selective inhibitor of eukaryotic DNA polymerase α (pol α), exhibiting an IC50 of 0.68 μM. It can be isolated from the fungus Alternaria tenuis. The compound competitively inhibits the activity of DNA template primers (Ki: 0.23 μM) and non-competitively inhibits the activity of 2'-deoxyribonucleoside 5'-triphosphate substrates (Ki: 0.18 μM) . Additionally, (±) -Dehydroaltenusin can induce S-phase cell cycle arrest and apoptosis in cancer cells and is applicable in research on cancers such as human adenocarcinoma.
Smiles
O=C1OC2(C=C(O)C(=O)C=C2C=3C=C(OC)C=C(O)C13)C
Molecular Formula
C15H12O6
Molecular Weight
288.25
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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