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Progesterone Receptor Antibody

CAT: 0013-GTR18083254-01Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18083254-01Size:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
This mAb is specific to progesterone receptor and shows minimal cross-reaction with other members of the family. Progesterone receptor is expressed as two major isoforms, PR-A (81kDa) and PR-B (116kDa) . Expression of PgR has been suggested to reflect a intact estrogen regulatory machinery and therefore, predict better clinical response to endocrine therapy than ER alone.
UniProt
P06401
Reactivity
Human
Immunogen
Recombinant human protein was used as the immunogen for this anti-Progesterone Receptor antibody.
Clonality
Monoclonal
Clone
SPM566
Conjugation
Unconjugated
Field of Research
Pharmacology & Drug Discovery
Purification
Protein G affinity chromatography
Dilution
Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
The optimal dilution of the anti-Progesterone Receptor antibody for each application should be determined by the researcher.1. Staining of formalin-fixed tissues requires boiling tissue sections in pH 9 10mM Tris with 1mM EDTA for 10-20 min followed by cooling at RT for 20 minutes.2. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
Tested Applications
IHC-P
Host or Source
Mouse
Preservative
0.2 mg/ml in 1X PBS with 0.1 mg/ml rAlbumin and 0.05% sodium azide
Isotype
Mouse IgG1, kappa

UniProtKB · P06401

Progesterone receptor

PRGR_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P06401
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PGR
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
PR
EC number
—
Processing
—
Secondary accessions
A7LQ08, A7X8B0, B4E3T0, Q8TDS3, Q9UPF7
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative promoter usageAlternative splicing

Cellular component

CytoplasmMembraneMitochondrionMitochondrion outer membraneNucleus

Molecular function

DNA-bindingReceptor

PTM

Isopeptide bondLipoproteinPalmitatePhosphoproteinUbl conjugation

Ligand

Lipid-bindingMetal-bindingSteroid-bindingZinc

Biological process

TranscriptionTranscription regulation

Domain

Zinc-finger

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