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MRT68921 (hydrochloride)

CAT: 0804-HY-100006BSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-100006BSize:1 Each
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Description
MRT68921 hydrochloride is a potent NUAK1/ULK1 dual inhibitor. MRT68921 hydrochloride inhibits ULK1 and ULK2 with IC50 values of 2.9 nM and 1.1 nM, respectively. MRT68921 hydrochloride can block cells autophagy and kill tumor cells by breaking the balance of oxidative stress signals. MRT68921 hydrochloride can inhibit cell proliferation and induce ROS production and apoptosis. MRT68921 hydrochloride can be used for the research of cancer, such as breast cancer[1][2].
CAS Number
2070014-87-6
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Bcl-2 Family; GSK-3; Reactive Oxygen Species (ROS) ; ULK
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mrt68921-hydrochloride-1.html
Solubility
10 mM in DMSO
Smiles
O=C(C1CCC1)NCCCNC2=NC(NC3=CC4=C(CN(C)CC4)C=C3)=NC=C2C5CC5.[H]Cl
Molecular Formula
C25H35ClN6O
Molecular Weight
471.04
Precautions
H302, H315, H319, H335
References & Citations
[1]Petherick KJ, et al. Pharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR) -dependent autophagy. J Biol Chem. 2015 May 1;290 (18) :11376-83.|[2]Chen Y, et al. Dual targeting of NUAK1 and ULK1 using the multitargeted inhibitor MRT68921 exerts potent antitumor activities. Cell Death Dis. 2020 Sep 1;11 (8) :712.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bcl-2; GSK-3β; ULK1; ULK2

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