MRT68921

CAT: 0804-HY-100006-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-100006-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

MRT68921 is a potent NUAK1/ULK1 dual inhibitor. MRT68921 inhibits ULK1 and ULK2 with IC50 values of 2.9 nM and 1.1 nM, respectively. MRT68921 can block cells autophagy and kill tumor cells by breaking the balance of oxidative stress signals. MRT68921 can inhibit cell proliferation and induce ROS production and apoptosis. MRT68921 can be used for the research of cancer, such as breast cancer[1][2].

CAS Number

1190379-70-4

UNSPSC

12352005

Hazard Statement

H315-H319-H320

Target

Apoptosis; Bcl-2 Family; GSK-3; Reactive Oxygen Species (ROS) ; ULK

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/MRT68921.html

Purity

99.71

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1CCC1)NCCCNC2=NC(NC3=CC4=C(CN(C)CC4)C=C3)=NC=C2C5CC5

Molecular Formula

C25H34N6O

Molecular Weight

434.58

Precautions

P264-P280-P302+P352-P305+P351+P338-P362

References & Citations

[1]Petherick KJ, et al. Pharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR) -dependent autophagy. J Biol Chem. 2015 May 1;290 (18) :11376-83.|[2]Chen Y, et al. Dual targeting of NUAK1 and ULK1 using the multitargeted inhibitor MRT68921 exerts potent antitumor activities. Cell Death Dis. 2020 Sep 1;11 (8) :712.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Bcl-2; GSK-3β; ULK1; ULK2

Citation 01

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MRT68921

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