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LXRB Antibody

CAT: 0013-GTR18082988-01Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18082988-01Size:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The liver X receptors, LXRA (NR1H3) and LXRB (NR1H2) form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors and regulate expression of target genes containing LXR response elements. LXRB can inhibit proliferation and induce apoptosis of cancer cells.
UniProt
P55055
Reactivity
Human
Immunogen
Recombinant full-length human NR1H2/LXRB protein was used as the immunogen for the LXRB antibody.
Clonality
Monoclonal
Clone
LXRB/2731
Conjugation
Unconjugated
Field of Research
Epigenetics
Purification
Protein G affinity chromatography
Dilution
ELISA: order Ab without BSA for coating
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Optimal dilution of the LXRB antibody should be determined by the researcher.
Tested Applications
ELISA
Host or Source
Mouse
Preservative
0.2 mg/ml in 1X PBS with 0.1 mg/ml rAlbumin and 0.05% sodium azide
Isotype
Mouse IgG2c, kappa

UniProtKB · P55055

Oxysterols receptor LXR-beta

NR1H2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P55055
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
NR1H2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
A8K490, B4DNM6, E7EWA6, Q12970, Q5I0Y1
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Molecular function

ActivatorDNA-bindingReceptor

Coding sequence diversity

Alternative splicing

PTM

Isopeptide bondUbl conjugation

Ligand

Metal-bindingZinc

Cellular component

Nucleus

Biological process

TranscriptionTranscription regulation

Domain

Zinc-finger

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