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LXRB Antibody

CAT: 0800-V8367SAF-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V8367SAF-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The liver X receptors, LXRA (NR1H3) and LXRB (NR1H2) form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors and regulate expression of target genes containing LXR response elements. LXRB can inhibit proliferation and induce apoptosis of cancer cells.
CAS Number
9007-83-4
Specifications
ELISA: order Ab without BSA for coating
UniProt
P55055
Host
Mouse
Reactivity
Human
Immunogen
Recombinant full-length human NR1H2/LXRB protein was used as the immunogen for the LXRB antibody.
Clonality
Monoclonal
Isotype
IgG2c κ
Clone
LXRB/2731
Applications
ELISA
Purity
Protein G affinity chromatography
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Store the LXRB antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This LXRB antibody is available for research use only.
Storage Conditions
Store the LXRB antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
Optimal dilution of the LXRB antibody should be determined by the researcher.
Location
Nuclear
Image Legend
SDS-PAGE analysis of purified, BSA-free LXRB antibody (clone LXRB/2731) as confirmation of integrity and purity.

UniProtKB · P55055

Oxysterols receptor LXR-beta

NR1H2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P55055
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
NR1H2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
A8K490, B4DNM6, E7EWA6, Q12970, Q5I0Y1
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Molecular function

ActivatorDNA-bindingReceptor

Coding sequence diversity

Alternative splicing

PTM

Isopeptide bondUbl conjugation

Ligand

Metal-bindingZinc

Cellular component

Nucleus

Biological process

TranscriptionTranscription regulation

Domain

Zinc-finger

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