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Cyclin D1 Antibody / CCND1

CAT: 0013-GTR18082778-01Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18082778-01Size:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Recognizes a protein of 36kDa, identified as cyclin D1. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t (11; 14) (q13; q32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative) . Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1.
UniProt
P24385
Reactivity
Human
Immunogen
A recombinant human partial protein (amino acids 115-270) was used as the immunogen for this Cyclin D1 antibody.
Clonality
Monoclonal
Clone
CCND1/3548
Conjugation
Unconjugated
Field of Research
Cancer Biology
Purification
Protein G affinity chromatography
Dilution
ELISA (order BSA-free format for coating)
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Optimal dilution of the Cyclin D1 antibody should be determined by the researcher.
Tested Applications
ELISA
Host or Source
Mouse
Preservative
0.2 mg/ml in 1X PBS with 0.1 mg/ml rAlbumin and 0.05% sodium azide
Isotype
Mouse IgG2b, kappa

UniProtKB · P24385

G1/S-specific cyclin-D1

CCND1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P24385
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CCND1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q6LEF0
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Biological process

Cell cycleCell divisionDNA damageTranscriptionTranscription regulation

Coding sequence diversity

Chromosomal rearrangement

Molecular function

CyclinRepressor

Cellular component

CytoplasmMembraneNucleus

PTM

Isopeptide bondPhosphoproteinUbl conjugation

Disease

Proto-oncogene

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