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Recombinant CELA3B Antibody / Elastase 3B

CAT: 0013-GTR18082651-01Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18082651-01Size:20 µg
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Description
This MAb recognizes a protein of ~30kDa, identified as CELA3B (Chymotrypsin like elastase family member 3B) . Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3B has little elastolytic activity. Like most of the human elastases, elastase 3B is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein; it has a digestive function in the intestine. Elastase 3B preferentially cleaves proteins after alanine residues. Elastase 3B may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1, and excretion of this protein in fecal material is frequently used as a measure of pancreatic function.
UniProt
P08861
Reactivity
Human
Immunogen
Amino acids 82-238 from the human protein were used as the immunogen for the recombinant CELA3B antibody.
Clonality
Recombinant
Clone
RCELA3B/1811
Conjugation
Unconjugated
Field of Research
Epigenetics
Purification
Protein G affinity chromatography
Dilution
Immunohistochemistry (FFPE) : 1-2ug/ml
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Optimal dilution of the recombinant CELA3B antibody should be determined by the researcher.
Tested Applications
IHC-P
Host or Source
Mouse
Preservative
0.2 mg/ml in 1X PBS with 0.1 mg/ml rAlbumin and 0.05% sodium azide
Isotype
Mouse IgG1, kappa

UniProtKB · P08861

Chymotrypsin-like elastase family member 3B

CEL3B_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P08861
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CELA3B
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.4.21.70
Processing
Precursor
Secondary accessions
B2RE44, P11423, Q5VU28, Q5VU29, Q5VU30
Protein keywords

Technical term

Direct protein sequencingProteomics identificationReference proteome

PTM

Disulfide bondGlycoproteinZymogen

Molecular function

HydrolaseProteaseSerine protease

Domain

Signal

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