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Elastase 3B Antibody / CELA3B

CAT: 0013-GTR18573297Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18573297Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six genes which encode the structurally similar proteins: Elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, 3B has little elastolytic activity. Like most of the human elastases, 3B is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein; it has a digestive function in the intestine. Elastase 3B preferentially cleaves proteins after alanine residues. It may also function in the intestinal transport and metabolism of cholesterol. Elastases 3A/B have been referred to as Protease E and as Elastase 1, and excretion of this protein in fecal material is frequently used as a measure of pancreatic function in clinical assays.
UniProt
P08861
Reactivity
Human, Mouse, Rat
Immunogen
A partial recombinant protein (aa 82-238) was used as the immunogen for the Elastase 3B antibody.
Clonality
Monoclonal
Clone
CELA3B/1257
Conjugation
Unconjugated
Purification
Protein G
Dilution
ELISA: 2-4ug/ml (order BSA/azide-free format), Western blot: 1-2ug/ml, Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Optimal dilution of the Elastase 3B antibody should be determined by the researcher.1. FFPE staining requires
Tested Applications
ELISA, IHC-P, WB
Host or Source
Mouse
Preservative
1 mg/ml in 1X PBS; rAlbumin free, sodium azide free
Isotype
Mouse IgG1, kappa

UniProtKB · P08861

Chymotrypsin-like elastase family member 3B

CEL3B_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P08861
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CELA3B
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.4.21.70
Processing
Precursor
Secondary accessions
B2RE44, P11423, Q5VU28, Q5VU29, Q5VU30
Protein keywords

Technical term

Direct protein sequencingProteomics identificationReference proteome

PTM

Disulfide bondGlycoproteinZymogen

Molecular function

HydrolaseProteaseSerine protease

Domain

Signal

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