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Parathyroid Hormone Antibody

CAT: 0013-GTR18082326-01Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18082326-01Size:20 µg
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Description
Parathyroid hormone (PTH), parathormone or parathyrin, is secreted by the chief cells of the parathyroid glands as a polypeptide containing 84 amino acids, yet effective hormone-receptor interaction requires solely the 34-N-terminal amino acids. While PTH acts to increase the concentration of ionic calcium (Ca2+) in the blood, calcitonin, a hormone produced by the parafollicular cells (C cells) of the thyroid gland, acts to decrease ionic calcium concentration. PTH essentially acts to increase the concentration of calcium in the blood by acting upon the parathyroid hormone 1 receptor, which is present at high levels in bone and kidney, and the parathyroid hormone 2 receptor, which is present at high levels in the central nervous system, pancreas, testis, and placenta. [Wiki]
UniProt
P01270
Reactivity
Human
Immunogen
A C-terminal partial recombinant protein from the human protein was used as the immunogen for the Parathyroid Hormone antibody.
Clonality
Monoclonal
Clone
PRTM1-3
Conjugation
Unconjugated
Field of Research
Metabolism Research
Purification
Protein G affinity chromatography
Dilution
Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT, Prediluted IHC only format: incubate for 30 min at RT (1)
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Titering of the Parathyroid Hormone antibody may be required for optimal performance.1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
Tested Applications
IHC-P
Host or Source
Mouse
Preservative
0.2 mg/ml in 1X PBS with 0.1 mg/ml rAlbumin and 0.05% sodium azide
Isotype
Mouse IgG2b, kappa

UniProtKB · P01270

Parathyroid hormone

PTHY_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P01270
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PTH
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
PTH
EC number
—
Processing
Precursor
Secondary accessions
Q4VB48, Q9UD38
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

Cleavage on pair of basic residues

Disease

Disease variant

Molecular function

Hormone

Cellular component

Secreted

Domain

Signal

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