Ki-67 Antibody

CAT: 0013-GTR18082119-01Size: 20 µgDry Ice: NoHazardous: No

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CAT#:0013-GTR18082119-01Size:20 µg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Ki67 antigen is a nuclear, non-histone protein that is present in all stages of the cell cycle except G0. This characteristic makes Ki67 an excellent marker for proliferating cells and is commonly used as one of the prognostic factors in cancer studies. A correlation has been demonstrated between Ki67 index and the histo-pathological grade of neoplasms. Assessment of Ki67 expression in renal and ureter tumors shows a correlation between tumor proliferation and disease progression, thus making it possible to differentiate high-risk patients. Ki-67 expression may also prove to be important for distinguishing between malignant and benign peripheral nerve sheath tumors. Ki67 labeling index has been shown to be a prognostic marker in a number of neoplasms including grade II astrocytoma, oligodendroglioma, colon carcinoma, and breast carcinoma. In general, Ki67 is a good marker of proliferating cell populations.

UniProt

P46013

Reactivity

Human

Immunogen

A portion of amino acids 2293-2478 was used as the immunogen for the Ki-67 antibody.

Clonality

Monoclonal

Clone

MKI67/2465

Conjugation

Unconjugated

Field of Research

Signal Transduction

Purification

Protein G affinity chromatography

Dilution

Flow cytometry: 1-2ug/million cells, Immunofluorescence: 1-2ug/ml, Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Notes

For research use only.

Applications Notes

Optimal dilution of the Ki-67 antibody should be determined by the researcher.

Tested Applications

FACS, IF, IHC-P

Host or Source

Mouse

Preservative

0.2 mg/ml in 1X PBS with 0.1 mg/ml rAlbumin and 0.05% sodium azide

Isotype

Mouse IgG2b, kappa

UniProtKB · P46013

Proliferation marker protein Ki-67

KI67_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P46013
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: MKI67
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: —
Secondary accessions: Q5VWH2

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationIsopeptide bondPhosphoproteinUbl conjugation

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingNucleotide-binding

Biological process

Cell cycle

Cellular component

ChromosomeNucleus

Molecular function

DNA-binding

Domain

Repeat

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Alternative Products

Catalog	Name
MBS2169887-01	Monoclonal Antibody to Ki-67 Protein (Ki-67)
CAU36144-01	Ki-67 Protein (Ki-67) Monoclonal Antibody
CAU24782-01	Ki-67 Protein (Ki-67) Polyclonal Antibody
TRV-004422-01	Polyclonal Antibody to Ki-67 Protein (Ki-67)
030367	Ki-67 (Antigen KI-67, MKI67, Ki67, Ki 67)
223782-01	Ki-67 (Antigen KI-67, MKI67, Ki67, Ki 67) discontinued