Nuvenzepine

CAT: 0804-HY-U00119-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-U00119-01Size:1 mg

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Description

Nuvenzepine is an mAChR antagonist, has the potential for gastrospasm treatment.

CAS Number

96487-37-5

UNSPSC

12352005

Target

MAChR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Nuvenzepine.html

Purity

99.67

Solubility

10 mM in DMSO

Smiles

O=C1C2=CC=CN=C2N(C(C3CCN(C)CC3)=O)C4=CC=CC=C4N1

Molecular Formula

C19H20N4O2

Molecular Weight

336.39

References & Citations

[1]Barocelli E, et al. Functional comparison between nuvenzepine and pirenzepine on different guinea pig isolated smooth muscle preparations. Pharmacol Res. 1994 Aug-Sep;30 (2) :161-70.|[2]Barocelli E, et al. Gastrointestinal activities of a new pirenzepine-analog, nuvenzepine, in the cat. Farmaco. 1990 Oct;45 (10) :1089-99.|[3]Caselli G, et al. Determination of nuvenzepine in human plasma by a sensitive [3H]pirenzepine radioreceptor binding assay. J Pharm Sci. 1991 Feb;80 (2) :173-7.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Chemical Information

Nuvenzepine

Nuvenzepine is a small molecule drug. The usage of the INN stem '-zepine' in the name indicates that Nuvenzepine is a tricyclic compound. Nuvenzepine has a monoisotopic molecular weight of 336.16 Da.

CAS Number	96487-37-5
PubChem CID	65846
IUPAC Name	11-(1-methylpiperidine-4-carbonyl)-6H-pyrido[3,2-c][1,5]benzodiazepin-5-one
Molecular Formula	C19H20N4O2
Molecular Weight	336.4
XLogP	1.5
Topological Polar Surface Area	65.5
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	1
Heavy Atom Count	25
Formal Charge	0
Complexity	518

SMILES

CN1CCC(CC1)C(=O)N2C3=CC=CC=C3NC(=O)C4=C2N=CC=C4

InChI

InChI=1S/C19H20N4O2/c1-22-11-8-13(9-12-22)19(25)23-16-7-3-2-6-15(16)21-18(24)14-5-4-10-20-17(14)23/h2-7,10,13H,8-9,11-12H2,1H3,(H,21,24)

InChIKey

HPKYRXAEGNUARA-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 96487-37-5

CID: 65846

Formula: C19H20N4O2

MW: 336.4

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	336.4
XLogP3	1.5
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	1
Exact Mass	336.15862589
Monoisotopic Mass	336.15862589
Topological Polar Surface Area	65.5 Å²
Heavy Atom Count	25
Formal Charge	0
Complexity	518
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
WDA48737-01	Nuvenzepine

Nuvenzepine

Chemical Information

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