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Prolactin Receptor Antibody

CAT: 0013-GTR18081651-01Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18081651-01Size:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
It recognizes a protein of 70kDa, identified as prolactin receptor. Prolactin is a pituitary hormone involved in the stimulation of milk production, salt and water regulation, growth, development and reproduction. The initial step in its action is the binding to a specific membrane receptor (prolactin receptor), which belongs to the superfamily of class 1 cytokine receptors. The function of the prolactin receptor is mediated, at least in part, by two families of signaling molecules: Janus kinases and signal transducers and activators of transcription.
UniProt
P16471
Reactivity
Human
Immunogen
Semi-purified human prolactin receptor was used as the immunogen for this Prolactin Receptor antibody.
Clonality
Monoclonal
Clone
B6.2
Conjugation
Unconjugated
Field of Research
Epigenetics
Purification
Protein G affinity chromatography
Dilution
Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
The optimal dilution of the Prolactin Receptor antibody for each application should be determined by the researcher.1. Staining of formalin-fixed tissues requires boiling tissue sections in pH 9 10mM Tris with 1mM EDTA for 10-20 min followed by cooling at RT for 20 minutes.2. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
Tested Applications
IHC-P
Host or Source
Mouse
Preservative
0.2 mg/ml in 1X PBS with 0.1 mg/ml rAlbumin and 0.05% sodium azide
Isotype
Mouse IgG1, kappa

UniProtKB · P16471

Prolactin receptor

PRLR_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P16471
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PRLR
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
PRL-R
EC number
—
Processing
Precursor
Secondary accessions
B2R882, D1MDP1, Q16354, Q8TD75, Q8TD78, Q96P35, Q96P36, Q9BX87, Q9UHJ5
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Disease

Disease variant

PTM

Disulfide bondGlycoprotein

Cellular component

MembraneSecreted

Ligand

Metal-bindingZinc

Molecular function

Receptor

Domain

RepeatSignalTransmembraneTransmembrane helix

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