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Oxfenicine

CAT: 0804-HY-W018026-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W018026-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Oxfenicine (L-p-Hydroxyphenylglycine) is an orally active carnitine palmitoyltransferase-1 inhibitor. Oxfenicine inhibits the oxidation of fatty acids in the heart, protecting cardiac tissue from necrotic damage during ischemia, and also has an inhibitory effect on cardiac tissue apoptosis. In addition, Oxfenicine promotes lipolysis in a high-fat diet rat model. Oxfenicine can be used in the study of cardiovascular and metabolic diseases[1][2][3][4][5].
CAS Number
32462-30-9
Product Name Alternative
L-p-Hydroxyphenylglycine; 4-Hydroxy-L-phenylglycine; UK 25842
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Acyltransferase; Apoptosis
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/h-phg-4-oh-oh.html
Concentration
10mM
Purity
99.97
Solubility
DMSO : < 1 mg/mL (ultrasonic) |H2O : 4.55 mg/mL (ultrasonic)
Smiles
O=C([C@H](C1=CC=C(C=C1)O)N)O
Molecular Formula
C8H9NO3
Molecular Weight
167.16
Precautions
H302, H315, H319, H335
References & Citations
[1]Stephens TW, et, al. Two mechanisms produce tissue-specific inhibition of fatty acid oxidation by oxfenicine. Biochem J. 1985 Apr 15;227 (2) :651-60.|[2]Greaves P, et, al. Cardiac hypertrophy in the dog and rat induced by oxfenicine, an agent which modifies muscle metabolism. Arch Toxicol Suppl. 1984;7:488-93.|[3]Kennedy JA, et al. Effect of perhexiline and oxfenicine on myocardial function and metabolism during low-flow ischemia/reperfusion in the isolated rat heart. J Cardiovasc Pharmacol. 2000 Dec;36 (6) :794-801.|[4]Sepa-Kishi DM, et al. Antilipolytic and antilipogenic effects of the CPT-1b inhibitor oxfenicine in the white adipose tissue of rats. Am J Physiol Regul Integr Comp Physiol. 2016 Oct 1;311 (4) :R779-R787.|[5]Kong JY, et al. Palmitate-induced cardiac apoptosis is mediated through CPT-1 but not influenced by glucose and insulin. Am J Physiol Heart Circ Physiol. 2002 Feb;282 (2) :H717-25.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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