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Tenascin C Antibody

CAT: 0013-GTR18081330-01Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18081330-01Size:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Tenascin C is a multifunctional, disulfide-linked hexameric extracellular matrix glycoprotein expressed in association with mesenchymal epithelial interactions during development and in the neo-vasculature and stroma of undifferentiated tumors. In adults, it is restricted to certain epithelial-stromal interfaces and increases markedly in hyper-proliferative diseases and in stroma of many neoplasms, including gliomas, breast, squamous and lung carcinomas.
UniProt
P24821
Reactivity
Human
Immunogen
Human breast carcinoma cells were used as the immunogen for the anti-Tenascin C antibody.
Clonality
Monoclonal
Clone
SPM319
Conjugation
Unconjugated
Field of Research
Epigenetics
Purification
Protein G affinity chromatography
Dilution
Immunohistochemistry (FFPE) : 2-4ug/ml for 30 min at RT
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Optimal dilution of the anti-Tenascin C antibody should be determined by the researcher.1. Staining of formalin-fixed tissues requires boiling tissue sections in pH 9 10mM Tris with 1mM EDTA for 10-20 min followed by cooling at RT for 20 min2. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
Tested Applications
IHC-P
Host or Source
Mouse
Preservative
0.2 mg/ml in 1X PBS with 0.1 mg/ml rAlbumin and 0.05% sodium azide
Isotype
Mouse IgG1, kappa

UniProtKB · P24821

Tenascin

TENA_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P24821
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
TNC
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
TN
EC number
—
Processing
Precursor
Secondary accessions
C9IYT7, C9J575, C9J6D9, C9J848, Q14583, Q15567, Q5T7S3
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

Cell adhesion

Domain

Coiled coilEGF-like domainRepeatSignal

Disease

DeafnessDisease variantNon-syndromic deafness

PTM

Disulfide bondGlycoproteinPhosphoproteinProteoglycan

Cellular component

Extracellular matrixSecreted

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