Desmethyl-VS-5584 (hydrochloride)

• UNSPSC Description:

  Desmethyl-VS-5584 hydrochloride is a dimethyl analog of VS-5584, a potent and selective mTOR/PI3KDual inhibitor[1].

• Target Antigen:

  mTOR; PI3K

• Type:

  Reference compound

• Related Pathways:

  PI3K/Akt/mTOR

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  cancer

• Assay Protocol:

  https://www.medchemexpress.com/desmethyl-vs-5584-hydrochloride.html

• Purity:

  98.63

• Solubility:

  DMSO : 2.67 mg/mL (ultrasonic;warming;adjust pH to 2 with HCl;heat to 60°C)

• Smiles:

  CC(N1C2=NC(N3CCOCC3)=NC(C(C=N4)=CN=C4N)=C2N=C1)C.Cl.Cl

• Molecular Weight:

  413.30

• References & Citations:

  [1]Hart S, et al. VS-5584, a novel and highly selective PI3K/mTOR kinase inhibitor for the treatment of cancer. Mol Cancer Ther. 2013;12(2):151-161.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Clinical Information:

  No Development Reported