Toxoflavin-13C4

Toxoflavin-13C4

• CAS Number: 2300178-70-3
• UNSPSC Description: Toxoflavin-13C4 is the 13C-labeled Toxoflavin. Toxoflavin (Xanthothricin) is an antagonist of transcription factor 4 (TCF4)/β-catenin complex, also acts as an inhibitor of KDM4A, with antitumor activity[1][2]. Antibiotic properties.
• Target Antigen: Antibiotic; Bacterial; Isotope-Labeled Compounds; β-catenin
• Type: Isotope-Labeled Compounds
• Related Pathways: Anti-infection;Others;Stem Cell/Wnt
• Field of Research: Cancer; Infection
• Assay Protocol: https://www.medchemexpress.com/toxoflavin-13c4.html
• Solubility: 10 mM in DMSO
• Smiles: O=[13C]([13C]1=N[13C]=NN(C)[13C]1=N2)N(C)C2=O
• Molecular Weight: 196.13
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Wei W, et al. Small molecule antagonists of Tcf4/beta-catenin complex inhibit the growth of HCC cells in vitro and in vivo. Int J Cancer. 2010 May 15;126(10):2426-36.|[3]Franci G, et al. Identification and characterization of PKF118-310 as a KDM4A inhibitor. Epigenetics. 2017 Mar 4;12(3):198-205.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported