Toxoflavin-13C4

• UNSPSC Description:

  Toxoflavin-13C4 is the 13C-labeled Toxoflavin. Toxoflavin (Xanthothricin) is an antagonist of transcription factor 4 (TCF4)/β-catenin complex, also acts as an inhibitor of KDM4A, with antitumor activity[1][2]. Antibiotic properties.

• Target Antigen:

  Antibiotic; Bacterial; Isotope-Labeled Compounds; β-catenin

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Anti-infection;Others;Stem Cell/Wnt

• Field of Research:

  Cancer; Infection

• Assay Protocol:

  https://www.medchemexpress.com/toxoflavin-13c4.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=[13C]([13C]1=N[13C]=NN(C)[13C]1=N2)N(C)C2=O

• Molecular Weight:

  196.13

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Wei W, et al. Small molecule antagonists of Tcf4/beta-catenin complex inhibit the growth of HCC cells in vitro and in vivo. Int J Cancer. 2010 May 15;126(10):2426-36.|[3]Franci G, et al. Identification and characterization of PKF118-310 as a KDM4A inhibitor. Epigenetics. 2017 Mar 4;12(3):198-205.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2300178-70-3