Imaradenant

CAT: 0804-HY-101980-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-101980-01Size:5 mg

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Description

AZD4635 (HTL1071) is a potent, selective and orally active adenosine A2A receptor (A2AR) antagonist. AZD4635 binds to human A2AR with a Ki of 1.7 nM and shows >30-fold selectivity over other adenosine receptors[1].

CAS Number

1321514-06-0

Product Name Alternative

HTL1071; AZD4635

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Adenosine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/AZD4635.html

Purity

99.68

Solubility

DMSO : ≥ 83.3 mg/mL

Smiles

NC1=NC(C2=CC=C(F)C=C2)=C(C3=CC(Cl)=NC(C)=C3)N=N1

Molecular Formula

C15H11ClFN5

Molecular Weight

315.73

Precautions

H302, H315, H319, H335

References & Citations

[1]Alexandra Borodovsky, et al. Abstract 5580: Preclinical pharmacodynamics and antitumor activity of AZD4635, a novel adenosine 2A receptor inhibitor that reverses adenosine mediated T cell suppression. AACR; Cancer Res 2017;77 (13 Suppl) :Abstract nr 5580.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 2

Chemical Information

Imaradenant

Imaradenant is under investigation in clinical trial NCT03381274 (Oleclumab (MEDI9447) Egfrm NSCLC Novel Combination Study).

CAS Number	1321514-06-0
PubChem CID	86676119
IUPAC Name	6-(2-chloro-6-methyl-4-pyridinyl)-5-(4-fluorophenyl)-1,2,4-triazin-3-amine
Molecular Formula	C15H11ClFN5
Molecular Weight	315.73
XLogP	2.6
Topological Polar Surface Area	77.6
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	2
Heavy Atom Count	22
Formal Charge	0
Complexity	366

SMILES

CC1=CC(=CC(=N1)Cl)C2=C(N=C(N=N2)N)C3=CC=C(C=C3)F

InChI

InChI=1S/C15H11ClFN5/c1-8-6-10(7-12(16)19-8)14-13(20-15(18)22-21-14)9-2-4-11(17)5-3-9/h2-7H,1H3,(H2,18,20,22)

InChIKey

NCWQLHHDGDXIJN-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 1321514-06-0

CID: 86676119

Formula: C15H11ClFN5

MW: 315.73

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	315.73
XLogP3	2.6
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	2
Exact Mass	315.0687012
Monoisotopic Mass	315.0687012
Topological Polar Surface Area	77.6 Å²
Heavy Atom Count	22
Formal Charge	0
Complexity	366
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
C18217-25mg	Imaradenant (AZD4635)

Imaradenant

Chemical Information

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