3'-O-DMTr-thymidine 5'-CE phosphoramidite

• UNSPSC Description:

  3’-O-DMTr-thymidine 5’-CE phosphoramidite is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

• Target Antigen:

  Nucleoside Antimetabolite/Analog

• Type:

  Oligonucleotides

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/3-o-dmtr-thymidine-5-ce-phosphoramidite.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(NC(C(C)=C1)=O)N1[C@@H]2O[C@H](COP(OCCC#N)N(C(C)C)C(C)C)[C@@H](OC(C3=CC=C(OC)C=C3)(C4=CC=CC=C4)C5=CC=C(OC)C=C5)C2

• Molecular Weight:

  744.81

• References & Citations:

  [1]Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  134031-86-0