AP2 alpha Antibody / TFAP2A / Activator protein 2

AP2 alpha Antibody / TFAP2A / Activator protein 2

• Description: TATA-box binding protein (TBP) interactions with TBP-associated factors (TAFs) are required for the transcription of RNA polymerases. One particular TBP-TAF complex, snRNA-activating protein complex (SNAPC), is unusual in that it regulates basal transcription of both RNA polymerase II and III by binding specifically to a non-TATA-box proximal sequence element (PSE). SNAPC consists of five subunits of varying size. SNAPC binds to Oct-1 and TBP, which are activators of snRNA and RNA polymerases, respectively. The POU domain of Oct-1 binds to SNAPC 190 and effectively recruits SNAPC to the PSE. The cooperative binding of SNAPC and Oct-1 to their respective sequence elements is mediated by a nucleosome positioned between the two sequence elements. SNAPC 19 mediates the assembly of the subunits to form a functional SNAPC transcription regulator. SNAPC 50 (also designated PTFbeta) contains two zinc finger motifs and binds to SNAPC 43 (also designated PTFGamma) but not SNAPC 45 (PTFdelta).
• CAS Number: 9007-83-4
• UniProt: P05549
• Host: Mouse
• Immunogen: Recombinant full-length human TFAP2A protein was used as the immunogen for the TFAP2A antibody.
• Clonality: Monoclonal
• Isotype: IgG2a
• Applications: FACS, IHC-P
• Format: Purified
• Buffer: 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
• Reconstitution: Aliquot the TFAP2A antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
• Limitations: This TFAP2A antibody is available for research use only.