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IGF2BP2 Antibody / IMP-2

CAT: 0800-V5017-20UGSize: 20 µgDry Ice: NoHazardous: No
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CAT#:0800-V5017-20UGSize:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
IGF2BP2 (Insulin-like growth factor 2 mRNA binding protein 2) is also known as IGF2 mRNA-binding protein 2, IMP-2 (IGF-II mRNA-binding protein 2), VICKZ family member 2 or hepatocellular carcinoma autoantigen p62 and is a 556 amino acid protein. IGF2BP2 is expressed in a variety of tissues including heart, placenta, skeletal muscle, pancreas, fetal liver, lung, kidney, thymus and gonadal cells. IGF2BP2 is an RNA binding protein which may be involved in the regulation of mRNA translation and may also function to control the spatial localization of target mRNAs. Antibodies against IGF2BP2 have been detected in patients with HCC (hepatocellular carcinoma), suggesting that IGF2BP2 may have a role in the pathogenesis of HCC. Defects in IGF2BP2 are thought to be associated with susceptibility to type two diabetes mellitus.
CAS Number
9007-83-4
Specifications
Flow cytometry: 1-2ug/million cells
UniProt
Q9Y6M1
Host
Mouse
Reactivity
Human
Immunogen
Recombinant full-length human IGF2BP2 protein was used as the immunogen for the IGF2BP2 antibody.
Clonality
Monoclonal
Isotype
IgG2 κ
Clone
PCRP-IGF2BP2-1F9
Applications
FACS
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the IGF2BP2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This IGF2BP2 antibody is available for research use only.
Storage Conditions
Aliquot the IGF2BP2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the IGF2BP2 antibody should be determined by the researcher.
Location
Nucleus
Image Legend
Analysis of a HuProt (TM) microarray containing more than 19,000 full-length human proteins using IGF2BP2 antibody (PCRP-IGF2BP2-1F9) . Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProt (TM) array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProt (TM) are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a mAb to its intended target. A mAb is considered to specific to its intended target, if the mAb has an S-score of at least 2.5. For example, if a mAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that mAb to protein X is equal to 29.

UniProtKB · Q9Y6M1

Insulin-like growth factor 2 mRNA-binding protein 2

IF2B2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9Y6M1
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
IGF2BP2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
IGF2 mRNA-binding protein 2, IMP-2
EC number
—
Processing
—
Secondary accessions
A0A4Z0, B3FTN2, B3FTN3, B3FTN4
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Coding sequence diversity

Alternative initiationAlternative splicing

Cellular component

CytoplasmNucleus

Biological process

mRNA transportTranslation regulationTransport

Domain

Repeat

Molecular function

RNA-binding

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