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EpCAM Antibody

CAT: 0800-V4917-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V4917-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
EGP40 is a 40-43kDa transmembrane epithelial glycoprotein, also identified as epithelial specific antigen (ESA), or epithelial cellular adhesion molecule (Ep-CAM) . It is expressed on baso-lateral cell surface in most simple epithelia and a vast majority of carcinomas. This antibody has been used to distinguish adenocarcinoma from pleural mesothelioma and hepatocellular carcinoma. This antibody is also useful in distinguishing serous carcinomas of the ovary from mesothelioma.
CAS Number
9000-83-3
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
P16422
Host
Mouse
Reactivity
Human, Cat, Dog
Immunogen
Recombinant full-length human protein was used as the immunogen for the EpCAM antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG1 k
Clone
REGP40/7334
Type
Recombinant
Applications
IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the EpCAM antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This EpCAM antibody is available for research use only.
Storage Conditions
Aliquot the EpCAM antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the EpCAM antibody should be determined by the researcher.
Location
Cell surface
Image Legend
IHC staining of FFPE dog liver with EpCAM / CD326 antibody (clone rEGP40/7334) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

UniProtKB · P16422

Epithelial cell adhesion molecule

EPCAM_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P16422
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
EPCAM
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
Ep-CAM
EC number
—
Processing
Precursor
Secondary accessions
P18180, Q6FG26, Q6FG49, Q96C47, Q9UCD0
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Cellular component

Cell junctionCell membraneMembraneTight junction

Disease

Disease variantHereditary nonpolyposis colorectal cancer

PTM

Disulfide bondGlycoprotein

Domain

RepeatSignalTransmembraneTransmembrane helix

Molecular function

Tumor antigen

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