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LIN28A Antibody

CAT: 0800-V4687-20UGSize: 20 µgDry Ice: NoHazardous: No
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CAT#:0800-V4687-20UGSize:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LIN-28 is a highly conserved, RNA-binding, cytoplasmic protein. It consists of a cold shock domain and retroviral-type (CCHC) zinc finger motifs that were first identified in Caenorhabditis elegans. LIN-28 controls the timing of events during embryonic development and is readily expressed in embryos, embryonic stem cells and embryonal carcinoma cells. The presence of LIN-28 persists in some adult tissues including cardiac and skeletal muscle. In differentiating myoblasts, LIN-28 increases protein synthesis efficiency and binds to the growth and differentiation factor IGF-II.
CAS Number
9007-83-4
Specifications
Flow cytometry: 1-2ug/million cells
UniProt
Q9H9Z2
Host
Mouse
Reactivity
Human
Immunogen
A recombinant partial protein sequence (within amino acids 134-187) from the human protein was used as the immunogen for the LIN28A antibody.
Clonality
Monoclonal
Isotype
IgG2a
Clone
PCRP-LIN28A-1E2
Applications
FACS
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the LIN28A antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This LIN28A antibody is available for research use only.
Storage Conditions
Aliquot the LIN28A antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the LIN28A antibody should be determined by the researcher.
Location
Nucleus
Image Legend
Flow cytometry testing of PFA-fixed human HeLa cells with LIN28A antibody (clone PCRP-LIN28A-1E2) followed by goat anti-mouse IgG-CF488 (blue), Red = unstained cells.

UniProtKB · Q9H9Z2

Protein lin-28 homolog A

LN28A_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9H9Z2
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
LIN28A
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
Lin-28A
EC number
—
Processing
—
Secondary accessions
—
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Cellular component

CytoplasmEndoplasmic reticulumNucleus

Ligand

Metal-bindingZinc

Domain

RepeatZinc-finger

Molecular function

RNA-binding

Biological process

RNA-mediated gene silencing

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