SDHB Recombinant Antibody / Succinate dehydrogenase B

• Description:

  Succinate dehydrogenase B (SDHB) is an iron-sulfur subunit of mitochondrial complex II, a key component of the citric acid cycle and the electron transport chain, a respiratory complex that catalyzes the oxidation of succinate in the mitochondrial membrane.Many cancers are generally positive for SDHB, including renal cell carcinomas and gastrointestinal stromal tumors. A subset of RCC and GIST tumors that are associated with SDH mutations, Carney-Stratakis Syndrome or Carney Triad exhibit a loss of SDHB expression.

• UniProt:

  P21912

• Host:

  Mouse

• Immunogen:

  A recombinant partial protein sequence (within amino acids 180-280) from the human protein was used as the immunogen for the recombinant SDHB antibody.

• Clonality:

  Monoclonal

• Isotype:

  IgG1 κ

• Type:

  Recombinant

• Applications:

  IHC-P

• Format:

  Purified

• Buffer:

  0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

• Reconstitution:

  Aliquot the recombinant SDHB antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

• Limitations:

  This recombinant SDHB antibody is available for research use only.

• CAS Number:

  9000-83-3