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PS2 Antibody

CAT: 0800-V4379-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V4379-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
It recognizes a polypeptide of 6.5kDa, identified as pS2 estrogen-regulated protein. Its epitope is located in the c-terminus of human pS2 protein. pS2 is a trefoil peptide. Trefoil peptides are protease resistant molecules secreted throughout the gut that play a role in mucosal healing. These peptides contain three intra-chain disulfide bonds, forming the trefoil motif, or P-domain. pS2 is known to form dimers and this dimerization is thought to play a role in its protective and healing properties. About 60% of breast carcinomas are positive for pS2. Staining is cytoplasmic, often with localization to the Golgi apparatus. pS2 is shown to be localized in normal stomach mucosa, gastric fluid, goblet cells in the colon and small intestine, and in ulcerations of the gastrointestinal tract. Several studies have shown that pS2 is primarily expressed in estrogen receptor-positive breast tumors and it may define a subset of estrogen-dependent tumors that displays an increased likelihood of response to endocrine therapy.
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 minutes at RT
UniProt
P04155
Host
Mouse
Reactivity
Human
Immunogen
A recombinant partial protein sequence (within amino acids 1-84) from the human protein was used as the immunogen for the pS2 antibody.
Clonality
Monoclonal
Isotype
IgG2a κ
Clone
TFF1/7767
Applications
IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the pS2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This pS2 antibody is available for research use only.
Storage Conditions
Aliquot the pS2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the pS2 antibody should be determined by the researcher.
Location
Cytoplasm
Image Legend
IHC staining of FFPE human stomach tissue with Transferrin antibody (clone TF/7767) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

UniProtKB · P04155

Trefoil factor 1

TFF1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P04155
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
TFF1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
—
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

Disulfide bond

Molecular function

Growth factor

Cellular component

Secreted

Domain

Signal

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