C/EBP epsilon Antibody / CEBPE

C/EBP epsilon Antibody / CEBPE

• Description: The transcription factor C/EBP Alpha (CCAAT-enhancer binding protein) is a heatstable, sequence-specific DNA-binding protein first purified from rat liver nuclei that binds avidly to several different cis-regulatory DNA sequences commonly associated with viral and cellular genes transcribed by RNA polymerase II. C/EBP Alpha regulates gene expression in a variety of tissues including liver, adipose, lung and intestine. C/EBP Alpha uses a bipartite structural motif to bind DNA. Two protein chains dimerize through a set of amphipathic Alpha helices termed the leucine zipper. Highly basic polypeptide regions emerge from the zipper to form a linked set of DNA contact surfaces. C/EBP Alpha appears to function exclusively in terminally differentiated, growth-arrested cells. Additional family members include C/EBP beta, C/EBP gamma, C/EBP delta and C/EBP epsilon, all of which exhibit similar DNA-binding specificities and affinities to C/EBP Alpha. Furthermore, C/EBP beta and C/EBP delta readily form heterodimers both with each other as well as with C/EBP Alpha.
• CAS Number: 9007-83-4
• UniProt: Q15744
• Host: Mouse
• Immunogen: Recombinant human protein was used as the immunogen for the C/EBP epsilon antibody.
• Clonality: Monoclonal
• Isotype: IgG2a
• Applications: FACS, IF
• Format: Purified
• Buffer: 1 mg/ml in 1X PBS; BSA free, sodium azide free
• Reconstitution: Aliquot the C/EBP epsilon antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
• Limitations: This C/EBP epsilon antibody is available for research use only.